Community Research Summary:
Paul J. Grippo, PhD
Associate Director, UICC Training & Ed.
Department of Medicine, UIC
Paul Grippo has been focused on the design
and utility of mouse models of cancer for over
20 years as he continues to generate new
mouse models, employing them in order to
understand the initiation and progression of GI
cancers including pancreatic and colorectal.
His research is focused on identifying defects
in cell signals which impact early stages of
cancer, typically called neoplasia. One specific
research focus is the effects of high fat diets on
altered genes leading to cancer. Paul’s work
has been funded by NIH/NCI, NIH/NIMHD,
Pancreatic Cancer Action Network, the
Lustgarten Foundation, the Rolfe Foundation,
and others. He has published more than 60
peer-reviewed articles and 5 chapters focused
on mouse models of cancer and their utility in
diet studies to measure their contribution at
various stages of disease.